Happened to me in work once... I was connected via SSH to one of our test machines, so I could test connection disruption handling on a product we had installed.

I had a script that added iptables rules to block all ports for 30 seconds then unblock them. Of course I didn't add an exception for port 22, and I didn't run it with nohup, so when I ran the script it blocked the ports, which locked me out of SSH access, and the script stopped running when the SSH session ended so never unblocked the ports. I just sat there in awe of my stupidity.