I don't think it does much, but any tiny contribution to the fight against climate change is a good for the world, as is any slowing of the erosion of civil rights domestically, gutting of what remains of medicare/medicaid, etc.
I also know a GOP administration will be worse in terms of fighting against leftist movements in the streets, if only slightly. They're definitely worse re: labor movements overall, again: even if only marginally.
So I'm not going to claim it's a panacea, or even someone that will have notable effects, but I do think it matters at the margins, so the effort required is usually worth it, IMHO
There's a podcast called Behind the Bastards, Robert Evans is the host. Podcast about terrible people in history, Evans and guests have left wing politics and "crude" humor...it's awesome