This is just my not-at-all-in-depth summary based on playing around with a few in VMs, but as a non-power-user:
Fedora Silverblue
Pros: Good support/documentation
Cons: barebones Gnome/required layering quite a few packages ~~if you want any kind of customization~~ before I could get my system up and running
OpenSUSE Aeon (MicroOS)
Pros: good number of built-in tools (e.g. Tweaks and Extension Manager)
Cons: documentation is sorely lacking
Vanilla OS
Pros: great ease of use/installation, container-centric
Cons: still very much a work in progress/small dev team